Dr. Mom blog explores Everything you Need to Know About the Flu, the Flu Shot, and Common Myths

Vaccines can be a controversial topic amongst parents.  In Canada, vaccines and anti-vaxxers (individuals who take an anti-vaccination approach to healthcare and parenting) have once again made the news.  On February 9, 2019, an outbreak of the measles was reported in Canada.

Unfortunately, this case is just one of many confirmed in North America.  The United States has also seen a huge rise in cases of the measles with dozens of confirmed cases in California, Colorado, Connecticut, Georgia, Illinois, Kentucky, New York, Oregon, Texas, and Washington.  The measles peaked in 2014 when the United States experienced 667 individual cases in 2014, including one large outbreak of 383 individual cases.

I understand why any mom worries about their child’s health. Everything from the food we feed them, to the medications a doctor prescribes them, to vaccines.  I think that it’s natural and healthy to question information you are given, because ultimately you want to make the best decisions for you and your little ones. Hopefully I can dispel some of those worries by explaining vaccines and why you definitely SHOULD get them.

Why did people start worrying about vaccines causing autism?

Part of the concern for the health effects vaccinations arose from an observation that the number of cases of autism worldwide appeared to almost double in the 1990s. In the medical community, it still is debated as to what “caused” this spike, but some suspect it was a change in the diagnostic definitions of autism, increased awareness of autism and other mental health disorders in children, and/or an increase in screening for autism.  Understandably, worried parents at the time began to search for what could be the “cause” of this perceived increase in autism.

Unfortunately, this perceived increase in the rates of autism in the 1990s also occurred at the same time that the number of recommended childhood vaccines increased. In the search for a cause for the “rise” in autism, some people suggested an association between the age in which children receive immunizations (just after 1 year old) and the onset of more significant symptoms of Autism.  This observation led to the (incorrect) belief that certain vaccines or additives within vaccines (thimerosal) may play a role in the development of autism.

A scientific paper was falsified, suggesting vaccines were linked to autism

The alleged association between vaccines and autism was first reported in the scientific community in 1998 through a study of ONLY 12 children.  This study suggested a link between recent injection of MMR vaccine (measles, mumps, rubella) coinciding with the onset of symptoms of autism in children.  

Long story short, in 2004, 10 of the 13 authors of this paper retracted the study’s interpretation that vaccines had any link to autism, the paper was deleted/unpublished from the journal (the Lancet), and an investigator found the study was actually fraudulent.   To make matters worse, the patients in the study were recruited through an anti-vaccine organization. We in the medical world would call this “some messed up s***.”

Another fraudulent study reports the presence of persistent measles virus in the intestinal tissue of 91 children with developmental disorders (which included a handful of children with Autism).  This study has also been highly criticized in the medical community for having flaws in data collection, inaccurate tools, and lacking a proper control group.

Debunking the myth about “Do vaccines cause autism”

Every single study suggesting that vaccinations cause autism or gut problems has been “debunked.”  Regardless, some people still add to the anti-vaccination smear campaign with arguments including “it’s better to get sick with the actual illness,” and “the immune system of a baby can’t handle all those vaccines.”

There are dozens, even hundreds, of studies showing the benefits of vaccines for all age groups.  Multiple large and very well-designed studies and systematic reviews (aka – studies that provide very good medical evidence) show absolutely no association between the MMR vaccine and autism.  

Children who receive vaccines have no increased rates of autism, compared to those who do not.

Studies investigating the risk for developing autism in children who have received the MMR vaccine vs those who have not received it showed absolutely no difference. These were all properly conducted studies.   

In 2014 a systematic review consisting of over half a million children found absolutely no relationship between the MMR vaccine and Autism.  This is significantly larger than any previous study that suggested a correlation between vaccines and Autism. Other well-designed studies also show absolutely no association between the symptoms or diagnosis of autism and:

1)     the age when children are first vaccinated

2)     The time since children were last vaccinated

3)     The date of vaccination

4)     The time since vaccination

What chaos and harm has the anti-vaxxer movement caused?

In 1960, there were almost 800,000 people diagnosed with  the measles. In early 2000 we had these numbers down to 0 thanks to vaccinations! Starting in 2008, there has been a resurgence of the measles coinciding with the anti-vaccination movement with thousands of documented cases (and rising).

Infectious diseases are making a comeback

Infectious diseases are making a comeback due to the anti-vaccination movement!  Measles, mumps, and pertussis – just to name a few.

In 1988 there were over 350,000 documented cases of polio (a very debilitating and deadly disease that can paralyze people and cause death by paralyzing the breathing muscles).  In 2018, there were only 29 reported cases. In fact, polio is very close to being eradicated thanks to vaccines – but the anti-vaxxer movement is threatening this every day.

The benefits of vaccination to not end with the individual

In my medical practice, and even in my own family, I notice that most people believe that the benefits of vaccination begin and end with the individual. But in fact, vaccines work via the power of the community.  This is why measles is making a comeback. Even if YOU have been vaccinated, YOU are still at risk of these diseases because your neighbour or a child at your kid’s school might not be.  In short, vaccines work very well to prevent deadly illnesses, but only if EVERYBODY (who can) gets them.

I know I may not be able to change people’s minds if its already made up, but if you’re on the fence about vaccines I hope this guide helps you decide.

I’ll end it here for this post, but please come back to Dr. Mom because I will post in the future about the preservatives in vaccines.  Some parents are worried about the preservatives (sodium ethylmercury and thiomersal) contained within most vaccines and the resulting effects on children’s health.  Spoiler alert: they also don’t cause autism.

Learn More from Dr. Mom

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Is sleep training safe?

How can I get a good nights rest? What is sleep hygiene?

How can I transition my toddler from 2 naps per day to one?

How much sleep does my baby need?

Going on vacation without your baby? what to know

References:

  1. Department of Developmental Services. Changes in the population of persons with autism and pervasive developmental disorders in California’s developmental services system: 1987 through 1998. A Report to the Legislature. California Health and Human Services, March 1, 1999. http://www.dds.ca.gov/Autism/docs/autism_report_1999.pdf (Accessed on October 05, 2011).
  2. Dales L, Hammer SJ, Smith NJ. Time trends in autism and in MMR immunization coverage in California. JAMA 2001; 285:1183.
  3. Madsen KM, Hviid A, Vestergaard M, et al. A population-based study of measles, mumps, and rubella vaccination and autism. N Engl J Med 2002; 347:1477.
  4. Madsen KM, Lauritsen MB, Pedersen CB, et al. Thimerosal and the occurrence of autism: negative ecological evidence from Danish population-based data. Pediatrics 2003; 112:604.
  5. Kaye JA, del Mar Melero-Montes M, Jick H. Mumps, measles, and rubella vaccine and the incidence of autism recorded by general practitioners: a time trend analysis. BMJ 2001; 322:460.
  6. Yeargin-Allsopp M, Rice C, Karapurkar T, et al. Prevalence of autism in a US metropolitan area. JAMA 2003; 289:49.
  7. McCormick MC. The autism “epidemic”: impressions from the perspective of immunization safety review. Ambul Pediatr 2003; 3:119.
  8. Developmental Disabilities Monitoring Network Surveillance Year 2010 Principal Investigators, Centers for Disease Control and Prevention (CDC). Prevalence of autism spectrum disorder among children aged 8 years – autism and developmental disabilities monitoring network, 11 sites, United States, 2010. MMWR Surveill Summ 2014; 63:1.
  9. Christensen DL, Baio J, Van Naarden Braun K, et al. Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 8 Years–Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2012. MMWR Surveill Summ 2016; 65:1.
  10. Baio J, Wiggins L, Christensen DL, et al. Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years – Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2014. MMWR Surveill Summ 2018; 67:1.
  11. Fombonne E. Epidemiology of pervasive developmental disorders. Pediatr Res 2009; 65:591.
  12. Wing L, Potter D. The epidemiology of autistic spectrum disorders: is the prevalence rising? Ment Retard Dev Disabil Res Rev 2002; 8:151.
  13. Shattuck PT. The contribution of diagnostic substitution to the growing administrative prevalence of autism in US special education. Pediatrics 2006; 117:1028.
  14. Wakefield AJ, Murch SH, Anthony A, et al. Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet 1998; 351:637.
  15. Wakefield AJ, Montgomery SM. Autism, viral infection and measles-mumps-rubella vaccination. Isr Med Assoc J 1999; 1:183.
  16. Bernard S, Enayati A, Redwood L, et al. Autism: a novel form of mercury poisoning. Med Hypotheses 2001; 56:462.
  17. Bernard S, Enayati A, Roger H, et al. The role of mercury in the pathogenesis of autism. Mol Psychiatry 2002; 7 Suppl 2:S42.
  18. Geier MR, Geier DA. Thimerosal in childhood vaccines, neurodevelopment disorders and heart disease in the United States. J Am Physicians Surg 2003; 8:6.
  19. Geier MR, Geier DA. Neurodevelopmental disorders after thimerosal-containing vaccines: a brief communication. Exp Biol Med (Maywood) 2003; 228:660.
  20. Gerber JS, Offit PA. Vaccines and autism: a tale of shifting hypotheses. Clin Infect Dis 2009; 48:456.
  21. Retraction–Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet 2010; 375:445.
  22. Murch SH, Anthony A, Casson DH, et al. Retraction of an interpretation. Lancet 2004; 363:750.
  23. Deer B. How the case against the MMR vaccine was fixed. BMJ 2011; 342:c5347.
  24. Deer B. Secrets of the MMR scare . How the vaccine crisis was meant to make money. BMJ 2011; 342:c5258.
  25. Deer B. Pathology reports solve “new bowel disease” riddle. BMJ 2011; 343:d6823.
  26. Deer B. More secrets of the MMR scare. Who saw the “histological findings”? BMJ 2011; 343:d7892.
  27. Deer B. Secrets of the MMR scare. The Lancet’s two days to bury bad news. BMJ 2011; 342:c7001.
  28. Uhlmann V, Martin CM, Sheils O, et al. Potential viral pathogenic mechanism for new variant inflammatory bowel disease. Mol Pathol 2002; 55:84.
  29. Immunization Safety Review: Measles-Mumps-Rubella Vaccine and Autism, Stratton K, Wilson CB, McCormick MC (Eds), The National Academies Press, Washington, DC 2001.
  30. Offit, PA. Vaccines and autism. Immunization Action Coalition. www.immunize.org/catg.d/p2065.htm (Accessed on January 18, 2006).
  31. Fombonne E, Chakrabarti S. No evidence for a new variant of measles-mumps-rubella-induced autism. Pediatrics 2001; 108:E58.
  32. Offit PA, Coffin SE. Communicating science to the public: MMR vaccine and autism. Vaccine 2003; 22:1.
  33. Taylor B, Miller E, Lingam R, et al. Measles, mumps, and rubella vaccination and bowel problems or developmental regression in children with autism: population study. BMJ 2002; 324:393.
  34. Immunization Safety Review: Vaccines and Autism. A report of the Institute of Medicine, National Academies Press, Washington, DC 2004.
  35. Evans AS. Causation and disease: a chronological journey. The Thomas Parran Lecture. 1978. Am J Epidemiol 1995; 142:1126.
  36. Kawashima H, Mori T, Kashiwagi Y, et al. Detection and sequencing of measles virus from peripheral mononuclear cells from patients with inflammatory bowel disease and autism. Dig Dis Sci 2000; 45:723.
  37. Fernell E, Fagerberg UL, Hellström PM. No evidence for a clear link between active intestinal inflammation and autism based on analyses of faecal calprotectin and rectal nitric oxide. Acta Paediatr 2007; 96:1076.
  38. Martin CM, Uhlmann V, Killalea A, et al. Detection of measles virus in children with ileo-colonic lymphoid nodular hyperplasia, enterocolitis and developmental disorder. Mol Psychiatry 2002; 7 Suppl 2:S47.
  39. Afzal MA, Ozoemena LC, O’Hare A, et al. Absence of detectable measles virus genome sequence in blood of autistic children who have had their MMR vaccination during the routine childhood immunization schedule of UK. J Med Virol 2006; 78:623.
  40. D’Souza Y, Fombonne E, Ward BJ. No evidence of persisting measles virus in peripheral blood mononuclear cells from children with autism spectrum disorder. Pediatrics 2006; 118:1664.
  41. Katz SL. Has the measles-mumps-rubella vaccine been fully exonerated? Pediatrics 2006; 118:1744.
  42. Cass H, Gringras P, March J, et al. Absence of urinary opioid peptides in children with autism. Arch Dis Child 2008; 93:745.
  43. Nagamitsu S, Matsuishi T, Kisa T, et al. CSF beta-endorphin levels in patients with infantile autism. J Autism Dev Disord 1997; 27:155.
  44. Gillberg C, Terenius L, Lönnerholm G. Endorphin activity in childhood psychosis. Spinal fluid levels in 24 cases. Arch Gen Psychiatry 1985; 42:780.
  45. Gillberg C, Terenius L, Hagberg B, et al. CSF beta-endorphins in childhood neuropsychiatric disorders. Brain Dev 1990; 12:88.
  46. Feldman HM, Kolmen BK, Gonzaga AM. Naltrexone and communication skills in young children with autism. J Am Acad Child Adolesc Psychiatry 1999; 38:587.
  47. Willemsen-Swinkels SH, Buitelaar JK, van Engeland H. The effects of chronic naltrexone treatment in young autistic children: a double-blind placebo-controlled crossover study. Biol Psychiatry 1996; 39:1023.
  48. Willemsen-Swinkels SH, Buitelaar JK, Weijnen FG, van Engeland H. Placebo-controlled acute dosage naltrexone study in young autistic children. Psychiatry Res 1995; 58:203.
  49. Baird G, Pickles A, Simonoff E, et al. Measles vaccination and antibody response in autism spectrum disorders. Arch Dis Child 2008; 93:832.
  50. Taylor B, Miller E, Farrington CP, et al. Autism and measles, mumps, and rubella vaccine: no epidemiological evidence for a causal association. Lancet 1999; 353:2026.
  51. Mäkelä A, Nuorti JP, Peltola H. Neurologic disorders after measles-mumps-rubella vaccination. Pediatrics 2002; 110:957.
  52. Farrington CP, Miller E, Taylor B. MMR and autism: further evidence against a causal association. Vaccine 2001; 19:3632.
  53. Patja A, Davidkin I, Kurki T, et al. Serious adverse events after measles-mumps-rubella vaccination during a fourteen-year prospective follow-up. Pediatr Infect Dis J 2000; 19:1127.
  54. Peltola H, Patja A, Leinikki P, et al. No evidence for measles, mumps, and rubella vaccine-associated inflammatory bowel disease or autism in a 14-year prospective study. Lancet 1998; 351:1327.
  55. Fombonne E, Zakarian R, Bennett A, et al. Pervasive developmental disorders in Montreal, Quebec, Canada: prevalence and links with immunizations. Pediatrics 2006; 118:e139.
  56. Uno Y, Uchiyama T, Kurosawa M, et al. Early exposure to the combined measles-mumps-rubella vaccine and thimerosal-containing vaccines and risk of autism spectrum disorder. Vaccine 2015; 33:2511.
  57. Jain A, Marshall J, Buikema A, et al. Autism occurrence by MMR vaccine status among US children with older siblings with and without autism. JAMA 2015; 313:1534.
  58. Jain A, Marshall J, Buikema A, et al. Correction of Description of MMR Vaccine Receipt Coding and Minor Errors in MMR Vaccine and Autism Study. JAMA 2016; 315:202.
  59. DeStefano F, Bhasin TK, Thompson WW, et al. Age at first measles-mumps-rubella vaccination in children with autism and school-matched control subjects: a population-based study in metropolitan atlanta. Pediatrics 2004; 113:259.
  60. Smeeth L, Cook C, Fombonne E, et al. MMR vaccination and pervasive developmental disorders: a case-control study. Lancet 2004; 364:963.
  61. Mrozek-Budzyn D, Kiełtyka A, Majewska R. Lack of association between measles-mumps-rubella vaccination and autism in children: a case-control study. Pediatr Infect Dis J 2010; 29:397.
  62. Goin-Kochel RP, Mire SS, Dempsey AG, et al. Parental report of vaccine receipt in children with autism spectrum disorder: Do rates differ by pattern of ASD onset? Vaccine 2016; 34:1335.
  63. Uno Y, Uchiyama T, Kurosawa M, et al. The combined measles, mumps, and rubella vaccines and the total number of vaccines are not associated with development of autism spectrum disorder: the first case-control study in Asia. Vaccine 2012; 30:4292.

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